| Autor: |
Thompson, Richard B, Rungwerth, Katrin, J Koch, Walter |
| Předmět: |
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| Zdroj: |
Annals of Medicine; May2004 Supplement 1, Vol. 36, p106-115, 10p |
| Abstrakt: |
Despite our continued advances in the management of coronary artery disease, there have been no significant reductions in the morbidity or mortality related to end- stage heart failure. The syndrome of heart failure represents a common endpoint for several disease processes, however, at the molecular level there are certain biochemical similarities common to all failing myocardium. Targeting these derangements with gene therapy represents a promising option in the treatment of heart failure. In this review, we will discuss the common biochemical changes that occur in the failing heart, novel therapeutic targets, including the β-adrenergic receptor system and intracellular calcium regulation, and the vectors and transfer methodology responsible for delivering these transgenes to the myocardium. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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