| Autor: |
Pereira, Anna Carolina Toledo da Cunha, de Siqueira, Tatiane Ribeiro, de Oliveira Prado, Andressa Anunciação, da Silva, Camila Almeida Veiga, de Fátima Silva Moraes, Thaís, Aleixo, Alan Alex, de Magalhaes, José Carlos, de Souza, Gabriel Augusto Pires, Drumond, Betânia Paiva, Ferreira, Gustavo Portela, de Mello Silva, Breno, de Brito Magalhães, Cintia Lopes, Santos, Luciana Lara, Ferreira, Jaqueline Maria Siqueira, Malaquias, Luiz Cosme Cotta, Coelho, Luiz Felipe Leomil |
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| Zdroj: |
Immunogenetics; Jun2018, Vol. 70 Issue 6, p355-362, 8p |
| Abstrakt: |
Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. A total of 1560 individuals were genotyped for polymorphisms in DC-SIGN (rs4804803), FcγRIIa (rs1801274), VDR (rs7975232), and TNF-α (rs1800629). The presence of anti-dengue antibodies (IgM and/or IgG) in these samples was also assayed. Anti-dengue antibodies were detected at an overall frequency of 16.86%, indicating a virus infection in asymptomatic individuals. The genotypic frequencies of all SNPs studied did not differ between the asymptomatic and control groups. Regarding the allelic frequencies of the four SNPs analyzed, a higher frequency was detected of the G allele of FcγRIIa/rs1801274 in the asymptomatic individuals when compared to that in the control group (p = 0.03). Therefore, the results showed a high prevalence of asymptomatic individuals in Minas Gerais State, with a potential association between the presence of the G allele of FcγRIIa/rs1801274 and protection against symptomatic disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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