| Autor: |
Levin, Myron J., Guang-Yun Cai, Lee, Katherine S., Rouphael, Nadine G., Mehta, Aneesh K., Canniff, Jennifer, Mulligan, Mark J., Weinberg, Adriana, Cai, Guang-Yun |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 4/1/2018, Vol. 217 Issue 7, p1105-1059, 5p |
| Abstrakt: |
We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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