Brain MRI Study in Thai Patient with Neuromyelitis Optica.

Autor: Sangwirotekun, Pattaranun, Tritanon, Oranan, Jindahra, Panitha, Pulkes, Teeratorn, Ratanakorn, Disya, Boonkongchuen, Pairoj, Dejthevaporn, Charungthai, Keandoungchun, Jesada, Preechawat, Pisit, Poonyathalung, Anuchit, Apiwattanakul, Metha, Laothamatas, Jiraporn, Tunlayadechanont, Supoch
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Zdroj: Journal of the Medical Association of Thailand; Jan2018, Vol. 101 Issue 1, p126-130, 5p
Abstrakt: Background: Neuromyelitis optica spectrum disease [NMOSD] is an in􀏐lammatory disease of the central nervous system involving optic nerve, spinal cord, and brain. Asymptomatic brain abnormalities were recorded in some countries but the data in Thailand were limited. Objective: To evaluate asymptomatic NMOSD brain abnormalities and their relation to clinical relapses in Thai patients. Materials and Methods: This was a retrospective study, recruiting 27 NMOSD patients in a tertiary care center in Thailand. All patients were seropositive for aquaporin-4 IgG. Magnetic resonance imaging [MRI] of the brain was performed in every case. Results: Twenty-four cases (88.89%) had asymptomatic hyperintensities on 􀏐luid-attenuated inversion recovery images [FLAIR]. These lesions were widespread across the brain even in areas with low density of aquaporin-4. To our knowledge, a fornix lesion was reported for the 􀏐irst time in a patient with acute optic neuritis. By using linear regression analysis, no signi􀏐icant correlation between annual relapse rate [ARR] and the number of asymptomatic FLAIR hyperintensities was established (coef􀏐icient 0.02, 95% con􀏐idence interval -0.0009 to 0.04, p = 0.06). Conclusion: Asymptomatic FLAIR hyperintensities on brain MRIs are frequently found in NMOSD. They may not correlate with clinical relapses. Further cohort studies are required. To our knowledge, this is the 􀏐irst report of a fornix lesion in a NMOSD patient presented with acute optic neuritis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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