| Autor: |
Thi Bich Thao Le, Thi Huyen Bui, Thi Minh Phuong Nguyen, Thi Minh Nguyet Tran, Huu Chi Do, Tien Dung Nguyen, Minh Dinh Pham, Doan Loi Do, Bich Nhi Nguyen, Van Chi Phan |
| Předmět: |
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| Zdroj: |
ScienceAsia; Oct2017, Vol. 43 Issue 5, p289-293, 5p |
| Abstrakt: |
The role of the 1562C>T single nucleotide polymorphism of the matrix metalloproteinase 9 (MMP-9) gene promoter in acute coronary syndrome (ACS) development has been reported in various populations. In this work, we investigated the association between MMP-9 1562C>T polymorphism and ACS patients in Vietnam. This study was conducted on 138 ACS patients and 68 control subjects recruited from the Vietnam National Heart Institute. The genotype of 1562C>T polymorphism was determined by RFLP-polymerase chain reaction and the serum MMP-9 level was measured by the ELISA method. We found that the frequencies of CT and TT genotypes in the ACS patients (30% and 4%) were higher than those in the control (18% and 1%). The 1562T allele in the MMP-9 promoter was found to have a significantly higher frequency in ACS patients than in control subjects (ACS versus control: 19% versus 10%, p = 0.001). Multiple logistic regression analysis indicated that the MMP-9 1562T allele carriers had an increased risk of developing ACS (odds ratio = 2.37; 95% confidence intervals: 1.04-5.75, p = 0.045). The serum MMP-9 level in the polymorphism-carrying group was considerably higher than in the group without polymorphism in both ACS patients (229±83 versus 194±108, p = 0.037) and controls (220±41 versus 171±80, p = 0.006). Our results showed that the MMP-9 1562C>T polymorphism is significantly associated with the ACS susceptibility in the Vietnamese population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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