| Abstrakt: |
Introduction: Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2) status are important predictive and prognostic factors in breast cancer and determination of their status is now standard practice. This is an attempt to study the ER, PR, and HER2 status in South Indian women with breast cancer. In addition, an attempt to validate the role of preanalytical factors in the reporting of hormone receptor (HR) and HER2 status was done by comparing the immunohistochemistry (IHC) staining results of needle core biopsies with that of large specimens in a subgroup of patients. Materials and Methods: This was a retrospective study from the archives of the Department of Pathology, KidwaiCancer Institute, from January 2010 to December 2016.Patients diagnosed with invasive breast cancer and available IHC reports of ER, PR and HER2 status were analyzed. The cases for the year 2016 formed a subgroup and that were analyzed further to observe the impact of preanalytical factors that might influence the IHC staining patterns of ER, PR, and HER2. Result: A total of 5436 patients were included in the study with a median age of 48 years (range, 18-94 years). The majority (65%) were pre or perimenopausal(<55years) with a median age of 44 years (range, 18-55 years). The remainder (>55years) had a median age of 63 years (range, 56-94 years). The overall incidence of HR+ patients (ER+/PR-; ER-/PR+; ER+/PR+) was 48%; HER2 enriched, 15%; and triple negative breast cancers (TNBC), 37%. The incidence of HR+, HER2 enriched and TNBC were 45%, 16%, 39%; and 53%, 13%, 34% in patients with age ?55 years and > 55years respectively (p<0.001). The role of preanalytical factors in IHC staining was analyzed in 930 patients for the year 2016. There was no significant difference in the staining patterns of ER, PR and HER2 when the IHC staining results of needle core biopsies were compared with those of large specimens. Conclusion: TNBC and younger age in Indian women account for a relatively large group when compared to their western counterparts. The median age of patients was 44years. Hormone positivity was higher in elderly patients whereas, the incidence of HER2 positive and TNBC cases was higher in the younger age group. There was no statistical difference in the patterns of ER, PR, and HER2 immunostaining based on IHC staining of core biopsy and large specimen. Corroborating that preanalytical factors did not account for negative HR staining. [ABSTRACT FROM AUTHOR] |
