| Autor: |
Muñoz, Laura S., Parra, Beatriz, Pardo, Carlos A., Makvandi-Nejad, Shokouh, Laurenson-Schafer, Henry, Wang, LiLi, Wellington, Dannielle, Zhao, Yan, Jin, Boquan, Qin, Ling, Kite, Kerry, Moghadam, Hooman K, Song, Chaojun, Clark, Kevin, Hublitz, Philip, Townsend, Alain R, Wu, Hao, McMichael, Andrew J, Zhang, YongHong, Dong, Tao |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 2017 Supplement, Vol. 216, pS897-S905, 9p |
| Abstrakt: |
Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes. Full-length IFITM3 protein can be detected in all genotypes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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