| Autor: |
Zakaria, Hadeer, Mostafa, Tarek, El-Azab, Gamal, Abd El Wahab, Ahmed, Elshahawy, Heba, Sayed-Ahmed, Nagy |
| Zdroj: |
International Urology & Nephrology; Oct2017, Vol. 49 Issue 10, p1851-1858, 8p |
| Abstrakt: |
Purpose: This study aimed to examine the impact of combined supplementation of fish oil (FO) with antioxidants like wheat germ oil (WGO) on mineral-bone and inflammatory markers in maintenance HD patients. Methods: This randomized, double-blind, placebo-controlled trial involved 46 HD patients who were randomly assigned into two groups to receive daily 3000 mg of FO [1053 mg omega-3 fatty acids (ω-3 FAs)] plus 300 mg of WGO [0.765 mg vitamin E] or placebo for 4 months. Blood concentrations of hemoglobin (Hgb), white blood cells, mineral-bone parameters including serum calcium (Ca), phosphorus, calcium-phosphorus product, parathyroid hormone, alkaline phosphatase, and osteoprotegerin and serum concentrations of inflammatory markers including high-sensitivity C-reactive protein, ferritin, and uric acid were measured before and after the intervention. Results: Eighty-seven percentage of patients in each group completed the study. The mean serum Ca levels increased significantly in the supplemented group at the end of study ( p = 0.0016), and this increment was also significant as compared to placebo group ( p = 0.0418). No significant alterations were observed in the other measured parameters within each group during the study (as p values were >0.05). Conclusion: FO plus WGO supplementation showed beneficial effect on serum Ca levels of HD patients without any statistically significant effect on other mineral-bone and inflammatory markers. Further investigations are required to confirm it. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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