Phenacyl group containing amide derivative of dehydroabietylamine exhibiting enhanced cytotoxic activity against PLC and MCF7 cancer cell lines.

Autor: Mustufa, Muhammad, Aslam, Afshan, Ozen, Cigdem, Ali Hashmi, Imran, Naqvi, Naim, Ozturk, Mehmet, Ali, Firdous
Zdroj: Medicinal Chemistry Research; Jul2017, Vol. 26 Issue 7, p1367-1376, 10p
Abstrakt: New amide derivatives of (+)-dehydroabietylamine, tricyclic abietane diterpene amine, were prepared using Zhongping's protocol. (+)- N-(2-phenyl-acetyl)-dehydroabietylamine derivative ( 11) demonstrated noticeable growth attenuation of hepatocellular carcinoma cell lines including PLC/PRF/5, SNU475, Hep3B-TR, and Huh7 with IC of 7.4 µM, 9.8 µM, 11.7 µM, and 11.8 µM, respectively. A breast cancer cell line MCF7 was the most sensitive against amide 11 with lowest IC value (4.8 µM). Low cell confluence and increase in G2/M phase was recorded after 48 and 72 h of treatment of amide 11 on PLC/PRF/5 cell line. Finally, amide 11 has comparatively sufficient therapeutic role due to addition of N-phenacyl group at C-18. Amide 11 demonstrated as potential candidate for future cancer interference and research. Graphical Abstract: [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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