Synthesis of 1β-hydroxydeoxycholic acid in H-2 and unlabeled forms.

Autor:	Hayes, Martin A., Roberts, Ieuan, Grönberg, Gunnar, Lv, Kexin, Lin, Baorui, Bergare, Jonas, Elmore, Charles S.
Předmět:	DEOXYCHOLIC acid CHEMICAL synthesis ISOTOPES CYTOCHROME P-450 BIOCATALYSIS NUCLEAR magnetic resonance
Zdroj:	Journal of Labelled Compounds & Radiopharmaceuticals; Apr2017, Vol. 60 Issue 4, p221-229, 9p
Abstrakt:	1β-hydroxydeoxycholic acid in unlabeled and stable isotope labeled forms was required for use as a biomarker for Cytochrome P450 3A4/5 activity. A lengthy synthesis was undertaken to deliver the unlabeled compound and in the process, to develop a route to the deuterium labeled compound. The synthesis of the unlabeled compound was completed but in a very low yield. Concurrent with the synthetic approach, a biosynthetic route was pursued and this approach proved to be much more rapid and afforded the compound in both unlabeled and deuterium labeled forms in a 1-step oxidation from deoxycholic acid and [D4]deoxycholic acid, respectively. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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