| Autor: |
Saminathan, Saranya, Saji, Elisabeth, Mehta, Parsshava, Damodharan, Suresh, Vijaidarshan, J. |
| Předmět: |
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| Zdroj: |
Indian Journal of Endocrinology & Metabolism; 2016 Ebsco Abstracts, Vol. 21, p29-29, 1p |
| Abstrakt: |
Calcium homeostasis during pregnancy and post-partum is an essential phenomenon to adequately favor calcium flux across the placenta during pregnancy and into breast milk in lactation. This ensures normal fetal and neonatal skeletal mineralisation. Any depletion in this, can progress to hypocalcemia. The exact cause and mechanism is not yet clear, but treating this condition is vital to avoid any complications. Case Study: A 24 year old female patient was received in OPD, 4 months post-partum with complaints of parasthesia, carpopedal-spasm and dyspnea. On examination, serum calcium-5.6 mg/dl (8.5-10.5 mg/dl) was unusually low; and serum phosphorous-5.4 mg/dl (2.5-4.8 mg/dl) was elevated, confirming severe symptomatic hypocalcemia, during early lactation. Hence, further investigation was warranted to identify exact cause. Results: The patient was evaluated and results revealed intact PTH-15.6 pg/ml (10-65 pg/ml) levels although inadequate for the degree of hypocalcemia. The vitamin D-46.1 ng/ml (21-100 ng/ml) levels were within the limits. This confirms postpartum hypoparathyroidism associated hypocalcemia with adequate vitamin D reserve in this patient. Conclusion: Pregnancy and lactation exert excessive strain on calcium requirements of the mother. Sub-clinical pathological calcium metabolism disorders in pregnant and lactating women are on a rise. This can be linked to over expression of PTHrP (Para- Thyroid Hormone receptor Proteins) in amniotic and breast tissue, during pregnancy and lactation, following which the levels of PTHrP drop drastically causing hypocalcemia with hypoparathyroidism. So, the risk of hypocalcemia peaks following labour, during early lactation and cessation of lactation. Thus, a step-wise endocrinological investigation, follow-up and work-out are key factors in such cases to prevent associated complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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