Identification by next-generation sequencing of Aichivirus B in a calf with enterocolitis and neurologic signs.

Autor: Moreira, Ana S. D., Raabis, Sarah M., Graham, Melissa E., Dreyfus, Jennifer M., Sibley, Samuel D., Godhardt-Cooper, Jennifer A., Toohey-Kurth, Kathy L., Goldberg, Tony L., Peek, Simon F.
Předmět:
Zdroj: Journal of Veterinary Diagnostic Investigation; Mar2017, Vol. 29 Issue 2, p208-211, 4p
Abstrakt: An 11-d-old Holstein bull calf was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin–Madison because of a 4-d history of diarrhea and persistent low-grade fever. Initial diagnosis was enteritis caused by Cryptosporidium and rotavirus. During hospitalization, the calf became stuporous and was only responsive to noxious stimuli, with hypotonia of all 4 limbs, tail, head, and neck. A cerebrospinal fluid analysis revealed xanthochromia, with marked lymphocytic pleocytosis, which was suggestive of viral meningitis and/or encephalitis. Aichivirus B, which belongs to the Kobuvirus genus, was tentatively identified in spinal fluid by next-generation DNA sequencing. This virus can affect a multitude of species, including humans and cattle, and has been isolated from both healthy and diarrheic individuals. However, to date, a possible connection with neurologic disease has not been described, to our knowledge. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index