Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study.

Autor: Martín-Trejo, Jorge Alfonso, Núñez-Enríquez, Juan Carlos, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Jiménez-Hernández, Elva, Amador-Sanchez, Raquel, Peñaloza-Gonzalez, José Gabriel, Alvarez-Rodriguez, Francisco Javier, Bolea-Murga, Victoria, Espinosa-Elizondo, Rosa Martha, de Diego Flores-Chapa, José, Pérez-Saldivar, Maria Luisa, Rodriguez-Zepeda, María del Carmen, Dorantes-Acosta, Elisa María, Núñez-Villegas, Nora Nancy, Velazquez-Aviña, Martha Margarita, Torres-Nava, José Refugio, Reyes-Zepeda, Nancy Carolina, González-Bonilla, César Raúl
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Zdroj: Leukemia & Lymphoma; Apr2017, Vol. 58 Issue 4, p898-908, 11p
Abstrakt: The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient’s age at diagnosis, gender, hospital of treatment, and socioeconomic status. Early mortality was high (12.1%) and malnutrition by different indicators was not associated with mortality at induction phase and at 6th month; a high risk of dying (RR = 2.08; 95% CI: 1.08–4.01) was observed in the group of malnourished children with a high-risk ALL. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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