| Autor: |
Wallace, I.R., McKinley, M.C., McEvoy, C.T., Hamill, L.L., Ennis, C.N., McGinty, A., Bell, P.M., Patterson, C.C., Woodside, J.V., Young, I.S., Hunter, S.J. |
| Předmět: |
|
| Zdroj: |
Clinical Endocrinology; Sep2016, Vol. 85 Issue 3, p386-392, 7p |
| Abstrakt: |
Context In observational studies, low serum 25-hydroxyvitamin D (25- OHD) concentration is associated with an increased risk of type 2 diabetes mellitus ( DM). Increasing serum 25- OHD may have beneficial effects on insulin resistance or beta-cell function. Cross-sectional studies utilizing suboptimal methods for assessment of insulin sensitivity and serum 25- OHD concentration provide conflicting results. Objective This study examined the relationship between serum 25- OHD concentration and insulin resistance in healthy overweight individuals at increased risk of cardiovascular disease, using optimal assessment techniques. Methods A total of 92 subjects (mean age 56·0, SD 6·0 years), who were healthy but overweight (mean body mass index 30·9, SD 2·3 kg/m2), underwent assessments of insulin sensitivity (two-step euglycaemic hyperinsulinaemic clamp, HOMA2- IR), beta-cell function ( HOMA2%B), serum 25- OHD concentration and body composition ( DEXA). Results Mean total 25- OHD concentration was 32·2, range 21·8-46·6 nmol/l. No association was demonstrated between serum 25- OHD concentration and insulin resistance. Conclusions In this study using optimal assessment techniques to measure 25- OHD concentration, insulin sensitivity and body composition, there was no association between serum 25- OHD concentration and insulin resistance in healthy, overweight individuals at high risk of developing cardiovascular disease. This study suggests the documented inverse association between serum 25- OHD concentration and risk of type 2 DM is not mediated by a relationship between serum 25- OHD concentration and insulin resistance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text