"Enjoy glass of wine before eating:" a randomized trial to test the orexigenic effects of this advice in advanced cancer patients.

Autor: Jatoi, Aminah, Qin, Rui, Satele, Daniel, Dakhil, Shaker, Kumar, Pankaj, Johnson, David, Thomas, Sachdev, Stella, Philip, Castillo, Jose, Li, Min, Fernandez-Zapico, Martin, Johnson, David B, Thomas, Sachdev P, Stella, Philip J
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Zdroj: Supportive Care in Cancer; Sep2016, Vol. 24 Issue 9, p3739-3746, 8p
Abstrakt: Background: Because the extant literature suggests wine increases appetite, this study sought to determine whether this effect could be observed in advanced cancer patients with appetite loss.Methods: Advanced cancer patients with self-reported loss of appetite were randomly assigned to white wine with ≤15 % alcohol content twice a day for 3-4 weeks versus a nutritional supplement, such as Boost® or Ensure®. Patients assigned to wine were encouraged to also take a nutritional supplement, whereas patients assigned to the nutritional supplement arm were told to abstain completely from alcohol. Patient-reported outcomes were captured with a validated questionnaire to assess the primary endpoint of appetite improvement.Results: A total of 141 patients (118 evaluable) were enrolled. Twenty-eight patients (48 %) in the wine arm reported an improvement in appetite at some point during the treatment period, whereas 22 patients (37 %) assigned to the nutritional supplement arm also reported improvement (p = 0.35). Other appetite-related questions and questionnaire items showed no statistically significant differences between treatment arms. In both arms, approximately 9 % of patients achieved weight stability (p = 0.98); median survival was not statistically different. Both interventions were well tolerated.Conclusion: As prescribed in this trial, wine does not improve appetite or weight in advanced cancer patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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