Rationale and design for an investigation to optimize selective serotonin reuptake inhibitor treatment for pregnant women with depression.

Autor:	Avram, MJ, Stika, CS, Rasmussen‐Torvik, LJ, Ciolino, JD, Pinheiro, E, George, AL, Wisner, KL
Předmět:	PHARMACOKINETICS DRUG metabolism OBSTETRICAL pharmacology SEROTONIN uptake inhibitors PREGNANCY complications
Zdroj:	Clinical Pharmacology & Therapeutics; Jul2016, Vol. 100 Issue 1, p31-33, 3p
Abstrakt:	The physiological changes of pregnancy can affect the pharmacokinetics of a drug, thereby affecting its dose requirements. Because pharmacokinetic (PK) studies in pregnant women have rarely been conducted, evidence-based dosing adjustments are seldom available. In particular, despite the fact that the use of antidepressants has become increasingly common, pregnancy-associated PK changes of the selective serotonin reuptake inhibitors (SSRIs) are largely unknown. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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