| Autor: |
Israni, Anil V., Dave, Divya A., Mandal, Anirban, Singh, Amitabh, Sahi, Puneet K., Das, Rashmi Ranjan, Shah, Arpita |
| Předmět: |
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| Zdroj: |
Journal of Neurosciences in Rural Practice; Jul-Sep2016, Vol. 7 Issue 3, p400-404, 5p |
| Abstrakt: |
Context: Childhood tuberculosis is a major public health problem in developing countries with tubercular meningitis being a serious complication with high mortality and morbidity. Aim: To study the clinicopathological as well as radiological profile of childhood tuberculous meningitis (TBM) cases. Settings and Design: Prospective, observational study including children <14 years of age with TBM admitted in a tertiary care hospital from Western India. Subjects and Methods: TBM was diagnosed based on predefined criteria. Glassgow coma scale (GCS) and intracranial pressure (ICP) was recorded. Staging was done as per British Medical Council Staging System. Mantoux test, chest X-ray, cerebrospinal fluid (CSF) examination, neuroimaging, and other investigations were done to confirm TB. Statistical Analysis Used: STATA software (version 9.0) was used for data analysis. Various risk factors were determined using Chi-square tests, and a P < 0.05 was considered significant. Results: Forty-seven children were included, of which 11 (24.3%) died. Fever was the most common presenting symptom, and meningismus was the most common sign. Twenty-nine (62%) children presented with Stage III disease. Stage III disease, low GCS, and raised ICP were predictors of mortality. Findings on neuroimaging or CSF examination did not predict mortality. Conclusions: Childhood TBM presents with nonspecific clinical features. Stage III disease, low GCS, lack of Bacillus Calmette--Guérin vaccination at birth and raised ICP seem to the most important adverse prognostic factors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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