| Autor: |
Parker, SE, Jick, SS, Werler, MM, Parker, S E, Jick, S S, Werler, M M |
| Předmět: |
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| Zdroj: |
BJOG: An International Journal of Obstetrics & Gynaecology; Apr2016, Vol. 123 Issue 5, p788-795, 8p |
| Abstrakt: |
Objective: To determine the association between intrauterine device (IUD) use, timing of removal prior to pregnancy, and the risk of pre-eclampsia.Design: A case-control study within the Clinical Practice Research Datalink, UK.Setting: Medical record database in the UK.Sample: Cases of pre-eclampsia (n = 2744) were identified among pregnancies resulting in singleton deliveries from 1993 to 2010. Four controls, or pregnancies unaffected by pre-eclampsia, were matched to each case on maternal age, general practice, and year of delivery.Methods: Data on IUD use were obtained from patient records. The odds ratios (ORs) for the association between IUD and pre-eclampsia were adjusted for covariates identified a priori, and analyses were stratified by BMI and number of prior deliveries.Main Outcome Measures: Odds ratios (95% confidence intervals, 95% CIs) of pre-eclampsia in pregnancies among women with a history of IUD use, compared with women without a history of IUD use.Results: Prior IUD use was associated with a reduced risk of pre-eclampsia (OR 0.76; 95% CI 0.58-0.98). The timing of removal in relation to the start of pregnancy showed an inverse association, with shorter intervals associated with a larger decrease in risk of pre-eclampsia. IUD removal within a year prior to pregnancy had an OR of 0.68 (95% CI 0.46-1.00). Among women with a prior delivery, the association between IUD use and pre-eclampsia was null.Conclusions: Intrauterine device use is associated with a small decreased risk of pre-eclampsia, specifically if removed within the year prior to conception.Tweetable Abstract: A case-control study of pregnancies in the UK suggests a reduced risk of pre-eclampsia for former IUD users. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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