| Autor: |
Gama, Ricardo Ribeiro, Carvalho, André Lopes, Filho, Adhemar Longatto, Scorsato, Anderson Paulo, López, Rossana V. Mendoza, Rautava, Jaana, Syrjänen, Stina, Syrjänen, Kari |
| Zdroj: |
Laryngoscope; Apr2016, Vol. 126 Issue 4, p885-893, 9p |
| Abstrakt: |
Background: Recent studies have reported a human papillomavirus (HPV) prevalence of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data on HPV involvement remain largely inconsistent, ascribed by some to differences in HPV detection methods or in geographic origin of the studies.Objective: To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in LSCC.Methods: Literature was searched from January 1964 until March 2015. The effect size was calculated as event rates (95% confidence interval [CI]), with homogeneity testing using Cochran's Q and I(2) statistics. Meta-regression was used to test the impact of study-level covariates (HPV detection method, geographic origin) on effect size. Potential publication bias was estimated using funnel plot symmetry.Results: One hundred seventy nine studies were eligible, comprising a sample size of 7,347 LSCCs from different geographic regions. Altogether, 1,830 (25%) cases tested HPV-positive considering all methods, with effect size of 0.269 (95% CI: 0.242 to 0.297; random-effects model). In meta-analysis stratified by the 1) HPV detection technique and 2) geographic study origin, the between-study heterogeneity was significant only for geographic origin (P = .0001). In meta-regression, the HPV detection method (P = .876) or geographic origin (P = .234) were not significant study-level covariates. Some evidence for publication bias was found only for studies from North America and those using non-polymerase chain reaction methods, with a marginal effect on adjusted point estimates for both.Conclusions: Variability in HPV detection rates in LSCC is explained by geographic origin of study but not by HPV detection method. However, they were not significant study-level covariates in formal meta-regression.Level Of Evidence: NA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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