| Autor: |
Veselkina, O., Solovtsova, I., Petrishchev, N., Galebskaya, L., Borovitov, M., Nilov, D., Solov'eva, M., Vorob'ev, E., Len'shina, K. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Feb2016, Vol. 49 Issue 11, p743-748, 6p |
| Abstrakt: |
The hemolytic activity of N, N′-substituted piperazines and their influence on the hemolytic process initiated by radiation (red LED, 653 nm) in the presence of radachlorin (RADA-FARMA, Russia) photosensitizer and on complement-dependent hemolysis were studied. All compounds did not cause human RBC lysis in the studied concentration range (0.15 - 3.0 mM) although dose-dependent inhibition of photo-induced hemolysis that manifested as an increase of the 50% lysis time was observed. The piperazine derivatives did not substantially influence RBC lysis by the activated complement. Therefore, the antihemolytic effect of the N, N'-substituted piperazines was due to their antioxidant activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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