| Autor: |
Yang, Ben, Feng, Yun Jiang, Vu, Hoan, McCormick, Brendan, Rowley, Jessica, Pedro, Liliana, Crowther, Gregory J., Van Voorhis, Wesley C., Forster, Paul I., Quinn, Ronald J. |
| Zdroj: |
Journal of Biomolecular Screening; Feb2016, Vol. 21 Issue 2, p194-200, 7p |
| Abstrakt: |
Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS or ESI-FTMS) was used to screen 192 natural product extracts and a 659-member natural product-based fragment library for bindings to a potential malaria drug target, Plasmodium falciparum Rab11a (PfRab11a, PF13_0119). One natural product extract and 11 fragments showed binding activity. A new natural product, arborside E, was identified from the active extract of Psydrax montigena as a weak binder. Its binding activity and inhibitory activity against PfRab11a were confirmed by ESI-FTMS titration experiments and an orthogonal enzyme assay. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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