| Autor: |
Shiba, Norio, Ohki, Kentaro, Kobayashi, Tohru, Hara, Yusuke, Yamato, Genki, Tanoshima, Reo, Ichikawa, Hitoshi, Tomizawa, Daisuke, Park, Myoung‐ja, Shimada, Akira, Sotomatsu, Manabu, Arakawa, Hirokazu, Horibe, Keizo, Adachi, Souichi, Taga, Takashi, Tawa, Akio, Hayashi, Yasuhide |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Feb2016, Vol. 172 Issue 4, p581-591, 11p |
| Abstrakt: |
Recent reports described the NUP98- NSD1 fusion as an adverse prognostic marker for acute myeloid leukaemia ( AML) and PRDM16 (also known as MEL1) as the representative overexpressed gene in patients harbouring NUP98- NSD1 fusion. PRDM16 gene expression levels were measured via real-time polymerase chain reaction in 369 paediatric patients with de novo AML, of whom 84 (23%) exhibited PRDM16 overexpression ( PRDM16/ ABL1 ratio ≥0·010). The frequencies of patients with high or low PRDM16 expression differed widely with respect to each genetic alteration, as follows: t(8;21), 4% vs. 96%, P < 0·001; inv(16), 0% vs. 100%, P < 0·001; KMT2A (also termed MLL)- partial tandem duplication, 100% vs. 0%, P < 0·001; NUP98- NSD1, 100% vs. 0%, P < 0·001. The overall survival ( OS) and event-free survival ( EFS) among PRDM16-overexpressing patients were significantly worse than in patients with low PRDM16 expression (3-year OS: 51% vs. 81%, P < 0·001, 3-year EFS: 32% vs. 64%, P < 0·001) irrespective of other cytogenetic alterations except for NPM1. PRDM16 gene expression was particularly useful for stratifying FLT3-internal tandem duplication-positive AML patients (3-year OS: high = 30% vs. low = 70%, P < 0·001). PRDM16 overexpression was highly recurrent in de novo paediatric AML patients with high/intermediate-risk cytogenetic profiles and was independently associated with an adverse outcome. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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