Ornidazole induced fixed drug eruption affecting the mouth and the palms.

Autor: Ghosh, Souvik, Achar, Arun, Mandal, Pragnadyuti, Mohata, Anju, Bisai, Samiran
Zdroj: Egyptian Dermatology Online Journal; Dec2013, Vol. 9 Issue 2, p1-5, 5p
Abstrakt: Fixed drug eruptions (FDE) are common cutaneous adverse drug reaction observed in clinical practice. Ornidazole, a 5-nitroimidazole antiamoebic drug, is not a very well known cause of FDE. Few cases of ornidazole induced FDE had been reported so far. However, another nitroimidazole antiamoebic drug metronidazole is a common offender for causing FDE. We report a 37 year old female patient who developed severe pain and burning sensation within the mouth about 3 to 4 hours after the intake of the first dose of ornidazole. On examination it was found that the patient had developed FDE in the oral cavity and lips. Next day she developed FDE in the palm of both hands. Ornidazole was withdrawn and she was prescribed oral prednisolone 40 mg daily along with povidone iodine mouth wash. The lesions got resolved in next 6 to 7 days. We found a probable association between this FDE and ornidazole. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index