| Autor: |
Overkleeft, Esther N.M., Zuidervaart, Wicke, Monique, H., Hurks, H., Eilers, Paul H.C., de Wolff-Rouendaal, Didi, Jager, Martine J. |
| Předmět: |
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| Zdroj: |
Archives of Ophthalmology; Oct2003, Vol. 121 Issue 10, p1398, 6p |
| Abstrakt: |
Objective: To evaluate whether nuclear activity as measured by the disodium phosphate [sup 32]P ([sup 32]P) uptake test for uveal melanoma is of prognostic value and corresponds to known prognostic factors. Methods: A retrospective analysis of 121 patients with choroidal and/or ciliary body melanoma, tested with the [sup 32]P uptake test before enucleation between January 1, 1973, and December 31, 1976, at the Leiden University Medical Center. We obtained the 25-year follow-up information of this group of patients and compared the [sup 32]P test results and histopathological variables with the long-term survival rates. Results: The cumulative 5-, 10-, and 20-year survival for melanoma-related death was 81.4%, 73.3%, and 63.9%, respectively. The results of the [sup 32]P uptake test were not significantly correlated with survival (P = .35). Of all prognostic factors under study, tumor diameter, cell type, and mitotic count were identified as the most important prognostic markers for uveal melanoma in this group. Conclusions: The [sup 32]P isotope uptake test has no prognostic value for uveal melanoma. Moreover, the results of this study indicate that it is unlikely that cell activity as determined by [sup 32]P uptake involves mitotic activity of the tumor. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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