Effect of ACE inhibitors and AT1 receptor antagonists on pentylenetetrazole-induced convulsions in mice.

Autor: ukawski, Krzysztof, Czuczwar, Stanislaw Jerzy, Łukawski, Krzysztof, Czuczwar, Stanisław Jerzy
Zdroj: Neurological Sciences; May2015, Vol. 36 Issue 5, p779-781, 3p
Abstrakt: Experimental data show that some angiotensin-converting enzyme (ACE) inhibitors and angiotensin AT(1) receptor antagonists that are normally used as antihypertensive drugs can exert anticonvulsant-like activity against audiogenic seizures. In the current study, a number of ACE inhibitors (captopril, enalapril, cilazapril, perindopril and zofenopril) and AT(1) antagonists (losartan, telmisartan and candesartan) were examined against pentylenetetrazole (PTZ)-induced seizures in mice. Captopril (50 mg/kg) administered intraperitoneally significantly raised the PTZ threshold (p < 0.05). The remaining drugs were not protective against PTZ-induced convulsions. The current study indicates that captopril decreases PTZ-evoked seizures in mice, which is an animal model of myoclonic convulsions. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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