| Autor: |
Counts, Debra R., Silverman, Lawrence a., Rajicic, Natasa, Geffner, Mitchell E., Newfield, Ron S., Thornton, Paul, Carakushansky, Mauri, Escobar, Oscar, Rapaport, Robert, Levitsky, Lynne, Rotenstein, Deborah, Hey-Hadavi, Judith, Wajnrajch, Michael P. |
| Předmět: |
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| Zdroj: |
Hormone Research in Paediatrics; Sep2015, Vol. 84 Issue 2, p79-87, 9p, 1 Diagram, 1 Chart, 3 Graphs |
| Abstrakt: |
Background/Aims: Growth hormone (GH) treatment regimens for children with non-GH-deficient, idiopathic short stature (ISS) have not been optimized. To compare the efficacy, efficiency, and safety of an individualized, target-driven GH regimen with standard weight-based dosing after 4 years of treatment. Methods: This is a 4-year, open-label, multicenter, randomized trial comparing individualized, formula-based dosing of Genotropin® versus a widely used ISS dose of Genotropin®. Subjects were prepubertal, had a bone age of 3-10 years for males and 3-9 years for females, were naive to GH treatment, and had a height standard deviation score (Ht SDS) of -3 to -2.25, a height velocity <25th percentile for their bone age, and peak stimulated GH >10 ng/ml. After the first 2 years, the individualized-dosing group was further randomized to either 0.18 or 0.24 mg/kg/week. Results: At 4 years, subjects in all treatment regimens achieved similar average height gains of +1.3 SDS; however, the individualized dosing regimen utilized less GH to achieve an equivalent height gain. Conclusion: Individualized, formula-based GH dosing, followed by a dose reduction after 2 years, provides a more cost-effective growth improvement in patients with ISS than currently employed weight-based regimens. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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