| Autor: |
Seraji‐Bozorgzad, Navid, Bao, Fen, George, Edwin, Krstevska, Shana, Gorden, Veronica, Chorostecki, Jessica, Santiago, Carla, Zak, Imad, Caon, Christina, Khan, Omar |
| Zdroj: |
Movement Disorders; Sep2015, Vol. 30 Issue 10, p1400-1404, 5p |
| Abstrakt: |
Introduction The value of biomarkers in early diagnosis and development of therapeutics in Parkinson's disease (PD) is well established. Methods We used proton magnetic resonance spectroscopy in a prospective, longitudinal study of 23 patients with early PD, naïve to dopaminergic therapy, and six age-matched healthy controls to examine the temporal changes in metabolic profile of substantia nigra over a period of 3 months. Results N-acetyl aspartate to creatine ratio at month 3 was compared with baseline values in the PD and control groups, as well as the side-to-side difference of the ratio at baseline. By month 3, n-acetyl aspartate to creatine ratio had decreased by 4.4% in patients with PD ( P = 0.024), without a concomitant change in healthy controls. The side-to-side asymmetry was significantly higher in the PD group (16.7%) vs. healthy controls (1.6%, P = 0.0024). Conclusion Estimation of change in the n-acetyl aspartate to creatine ratio appears to be a fast, quantifiable, and reliable marker of dopaminergic neuronal viability in PD. © 2015 International Parkinson and Movement Disorder Society [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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