| Autor: |
Vlassenko AG, Mintun MA, Xiong C, Sheline YI, Goate AM, Benzinger TL, Morris JC, Vlassenko, Andrei G, Mintun, Mark A, Xiong, Chengjie, Sheline, Yvette I, Goate, Alison M, Benzinger, Tammie L S, Morris, John C |
| Zdroj: |
Annals of Neurology; Nov2011, Vol. 70 Issue 5, p857-861, 5p |
| Abstrakt: |
Amyloid-beta (Aβ) accumulation was evaluated with 2 [(11)C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an ε4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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