Mode of Action of RNA/DNA Oligonucleotides.

Autor: Metz, Richard, DiCola, Mike, Kurihara, Takao, Bailey, Austin, Frank, Bruce, Roecklein, Bryan, Blaese, Michael
Předmět:
Zdroj: CHEST; Mar2002 Supplement, Vol. 121, p90S, 8p
Abstrakt: Describes a technology developed for the site-specific correction of a single base carried on an episome or chromosome in prokaryotic and eukaryotic cells. Standardized assay to study the mode of action and structure-activity relationships of α[sub 1]-antitrypsin deficiency; Positive selection system in Escherichia coli to assess RNA/DNA oligonucleotide (RDO)-directed repair activity.
Databáze: Complementary Index