| Autor: |
García, Antonio, Pelayo‐Negro, Ana L., Álvarez‐Paradelo, Silvia, Antolín, Francisco M., Berciano, José |
| Zdroj: |
Muscle & Nerve; Jul2015, Vol. 52 Issue 1, p39-44, 6p |
| Abstrakt: |
ABSTRACT Introduction: We analyzed the utility of tendon reflex (T-reflex) testing in Charcot-Marie-Tooth disease type 1A (CMT1A). Methods: A total of 82 subjects from 27 unrelated CMT1A pedigrees were evaluated prospectively. The series also comprised 28 adult healthy controls. Electrophysiology included evaluation of biceps T-reflex and soleus T-reflex. Results: Seventy-one individuals (62 adults and 9 children) had clinical and electrophysiological features of CMT1A. The remaining 11 (8 adults and 3 children) were unaffected. On electrophysiological testing, the biceps T-reflex was elicited in 58 of 62 (93%) adult CMT1A patients and in all 9 affected children. Latencies of the biceps T-reflex were always markedly prolonged, and a cut-off limit of 16.25 ms clearly separated adult patients and controls or unaffected kin adult individuals. In affected children, the soleus T-reflex latency was also prolonged when compared with age and height normative data. Conclusion: T-reflex testing is an accurate diagnostic technique for CMT1A patients. Muscle Nerve 52: 39-44, 2015 [ABSTRACT FROM AUTHOR] |
| Databáze: |
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