| Autor: |
GIORDANO, GIULIO, MONDELLO, PATRIZIA, TAMBARO, ROSA, PERROTTA, NICOLA, D'AMICO, FABIO, D'AVETA, ANTONIETTA, BERARDI, GIUSEPPE, CARABELLESE, BRUNO, PATRIARCA, ANDREA, CORBI, GRAZIA MARIA, DI MARZIO, LUIGI, LICIANCI, ANTONIETTA, BERARDI, DONATA, DI LULLO, LIBERATO, DI MARCO, ROBERTO |
| Předmět: |
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| Zdroj: |
Molecular & Clinical Oncology; 2015, Vol. 3 Issue 4, p41-44, 4p |
| Abstrakt: |
Several biosimilar versions of recombinant human erythropoietin are currently approved for use in Europe, including a biosimilar epoetin-α. The aim of this the study was to verify that biosimilar epoetin-α is similar in terms of efficacy, safety and cost to originator epoetin-α for the treatment of refractory anemia in patients with myelodysplastic syndrome. A total of 92 patients with myelodysplasia and refractory anemia were investigated. The patients received either originator (group A) or biosimilar (group B) epoetin-α. In addition, they received liposomal iron (Sideral®), calcium levofolinate and vitamin B12. Moreover, the median monthly overall costs were calculated for each group. The results demonstrated that hemoglobin (Hb) levels increased by 1 g/dl after a median time of 5 weeks in group A and 4 weeks in group B. In group A, a Hb level of >12 g/dl was achieved after 12 weeks, while in group B after 10.5 weeks. The median cost of therapy was 1,536 euros/month in group A and 1,354 euros/month in group B. A total of 5 patients required transfusion support in group A and 7 in group B. In conclusion, biosimilar epoetin-α appears to be comparable to originator epoetin-α in terms of efficacy and safety for the treatment of refractory anemia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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