Evaluating medication response in ADHD: cognitive, behavioral, and single-subject methodology.

Autor: Hale JB; School of Psychology Program, Moorhead State University, MN 56563, USA., Hoeppner JA, DeWitt MB, Coury DL, Ritacco DG, Trommer B
Jazyk: angličtina
Zdroj: Journal of learning disabilities [J Learn Disabil] 1998 Nov-Dec; Vol. 31 (6), pp. 595-607.
DOI: 10.1177/002221949803100610
Abstrakt: Although evidence supports the use of double-blind placebo medication trials to evaluate methylphenidate (MPH) effects on the core behavioral symptoms of attention-deficit/hyperactivity disorder (ADHD), few studies have demonstrated their utility in examining MPH effects on the cognitive deficits associated with ADHD. This article presents a technique for evaluating behavioral and cognitive dose-response relationships at the single-subject level of analysis. Case study results and multivariate analyses suggest that systematic evaluation of behavioral and cognitive MPH dose-response relationships could lead to more accurate MPH titration and greater long-term multimodal treatment efficacy.
Databáze: MEDLINE