| Autor: |
Maresco DL; Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH, USA., Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS |
| Jazyk: |
angličtina |
| Zdroj: |
Cytogenetics and cell genetics [Cytogenet Cell Genet] 1998; Vol. 82 (1-2), pp. 71-4. |
| DOI: |
10.1159/000015067 |
| Abstrakt: |
The human high-affinity receptor for immunoglobulin G, FcgammaRI (FCGR1), is encoded by a family of three genes that share over 95% sequence homology. Curiously, the three genes in this recently duplicated gene family flank the centromere of human chromosome 1, with FCGR1B located at 1p12 and both FCGR1A and FCGR1C located at 1q21. We have previously speculated that a pericentric inversion could account for the separation of the genes in the FCGR1 family and explain their current chromosomal location. Here we present evidence, obtained through fluorescence in situ hybridization analysis, that in the rhesus monkey (Macaca mulatta) and baboon (Papio papio) FCGR1 is located adjacent to the centromere on the chromosomal arm with greatest homology to human 1p, whereas in the chimpanzee (Pan troglodytes) it is located adjacent to the centromere on the chromosomal arm with greatest homology to human 1q. The separation of the FCGR1 gene family in humans suggests that the location of a second pericentric inversion, known to distinguish the human from the chimpanzee chromosome 1, is within the FCGR1 gene family. This finding refines the assignment of homology between the human and chimpanzee chromosomes 1. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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