[Changes in vascular wall, blood insulin spectrum and hemostasis system in patients with type II diabetes mellitus and relevant correction].
| Autor: | Iudanova LS, Starosel'tseva LK, Al'tshuler MIu |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 1998; Vol. 70 (6), pp. 20-3. |
| Abstrakt: | Aim: The study of insulin blood spectrum, capillary morphology (by evidence of skin biopsies), antithrombogenic activity of the vascular wall in patients with non-insulin-dependent diabetes mellitus; assessment of possible corrective therapy. Materials and Methods: 65 patients with type II diabetes mellitus (DM) entered the trial. Concentrations of free, bound, immunoreactive insulin (IRI) and C peptide were measured before and 10, 30, 60, 120 min after intravenous injection of glucose. Microcirculatory bed condition was evaluated by the data from skin biopsies. Antithrombogenic characteristics of the vascular wall were investigated at-test. Results: The tests discovered that DM patients had high IRI and low free insulin in high glucose levels; disorders of hemostasis, active proliferation in the microvessels. In patients with microangiopathy tiklid therapy given for 45 days reduced the speed and degree of platelet aggregation, improved fibrinolysis and clinical course of the disease. Conclusion: High level of IRI may be due to emergence of insulin-like substances dissociation of which produces peptides enhancing proliferative processes. |
| Databáze: | MEDLINE |
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