| Autor: |
Wang X; Nuffield Department of Anaesthetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxfordshire OX2 6HE, United Kingdom., Hole DG, Da Costa TH, Evans RD |
| Jazyk: |
angličtina |
| Zdroj: |
The American journal of physiology [Am J Physiol] 1998 Aug; Vol. 275 (2), pp. E265-71. |
| DOI: |
10.1152/ajpendo.1998.275.2.E265 |
| Abstrakt: |
Metabolism of nonesterified fatty acid (palmitate, 1.1 mM) and triacylglycerol (TAG; triolein, 0.4 mM in the form of both rat chylomicrons and very low density lipoproteins) was studied in isolated perfused working hearts from fed nulliparous, lactating, and weaned rats. Hearts from virgin rats oxidized palmitate readily, but optimal cardiac mechanical performance occurred during perfusion with chylomicrons. In hearts from lactating dams, there was a significant increase in palmitate oxidation and a marked decrease in TAG oxidation from both chylomicrons and very low density lipoproteins compared with hearts from nulliparous animals. There was a concomitant decrease in lipoprotein lipase activity in hearts from lactating animals, and TAG in the absence of palmitate could not support optimal cardiac mechanical function. After litter removal, the changes in fatty acid and TAG metabolism observed in lactation returned to nulliparous values within 96 h. These results suggest that, during lactation, both exogenous and endogenous TAGs are directed away from heart and toward the lactating mammary gland; the heart, therefore, has to rely to a greater extent on nonesterified fatty acid for energy provision under these conditions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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