| Autor: |
Rafael JA; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Hutchinson TL, Lumeng CN, Marfatia SM, Chishti AH, Chamberlain JS |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroreport [Neuroreport] 1998 Jun 22; Vol. 9 (9), pp. 2121-5. |
| DOI: |
10.1097/00001756-199806220-00039 |
| Abstrakt: |
Recent studies have begun to elucidate the localization of ion channels and receptors in central nervous system synapses. A family of proteins containing PDZ domains has been suggested to play essential roles in these processes. PSD-95 and chapsyn-110 have been implicated in the clustering of Shaker K+ channels and NMDA receptors in the mammalian brain, and Dlg plays a role in the clustering of Shaker K+ channels at the Drosophila neuromuscular junction (NMJ). We have explored whether Dlg might participate in mammalian NMJ organization. We demonstrate that Dlg is expressed in muscle and co-localizes with utrophin at the post-synaptic face of the mammalian NMJ. Dlg may therefore be important for establishing or maintaining the organization of protein complexes at the mammalian NMJ. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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