Reversal of the histology of bone after parathyroidectomy in patients with hyperparathyroidism.

Autor: Chavda DV; Division of Orthopaedic Surgery, Creighton University School of Medicine, Saint Joseph Hospital, Omaha, Neb 68131, USA., Frock JT, Zielinski CM, Walla DJ, McGuire MH
Jazyk: angličtina
Zdroj: Journal of the Southern Orthopaedic Association [J South Orthop Assoc] 1998 Spring; Vol. 7 (1), pp. 65-71.
Abstrakt: Hyperparathyroidism is commonly seen in patients with end-stage renal disease and less commonly in the primary form. The skeletal manifestations of hyperparathyroidism are the same in both forms and are well described in the literature. We treated a patient from each category. Multiple bony lesions and pathologic fractures were observed. The clinical presentations and radiologic and histologic findings confirmed the diagnosis of hyperparathyroidism and osteitis fibrosa cystica in both patients. Subtotal excisions of the parathyroid glands were done in both patients. Appropriate treatment of the bony lesions and pathologic fractures resulted in healing. Histologic evaluation of the bony lesions indicated an osteoblastic or healing response. The reversal of the histologic pattern in just 5 days and 16 days after parathyroidectomy was noted. In treating such patients, physicians should consider parathyroidectomy as an aid in the overall management of patients.
Databáze: MEDLINE