| Autor: |
Wallace MN; Department of Biomedical Sciences, University of Aberdeen, Scotland., Geddes JG, Farquhar DA, Masson MR |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental neurology [Exp Neurol] 1997 Apr; Vol. 144 (2), pp. 266-72. |
| DOI: |
10.1006/exnr.1996.6373 |
| Abstrakt: |
This study provides the first evidence that nitric oxide is released by astrocytes surrounding beta-amyloid plaques. Nitric oxide is involved in many neuropathological conditions and can have either a neuroprotective or a neurotoxic function depending on its concentration and the redox state of the tissue. It is produced by the enzyme nitric oxide synthase, which can be located by a simple histochemical technique for demonstrating NADPH diaphorase. Using this method we examined tissue from 10 brains where there were varying numbers of beta-amyloid plaques in the cerebral cortex. In the 6 brains with moderate or high densities of plaques, primitive and cored plaques were associated with between 1 and 10 reactive astrocytes that contained NADPH diaphorase or were immunoreactive for the inducible form of nitric oxide synthase. In the 4 brains which had only low densities of plaques, the plaques were not associated with diaphorase-containing astrocytes. The percentage of plaques associated with 1 or more NADPH diaphorase-containing astrocyte varied between 1 and 21% and was correlated with the density of plaques. Astrocytes were the only form of NADPH diaphorase-positive glial cell associated with the plaques. There was no evidence of any nitric oxide synthase occurring in microglia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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