| Autor: |
Böni R; Department of Dermatology, University Hospital of Zurich, Switzerland., Panizzon R, Huch Böni RA, Steinert H, Dummer R |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental dermatology [Clin Exp Dermatol] 1996 Nov; Vol. 21 (6), pp. 427-30. |
| DOI: |
10.1111/j.1365-2230.1996.tb00147.x |
| Abstrakt: |
Malignant blue naevus is a distinct but rarely documented variant of malignant melanoma, and we describe the triple recurrence of a suprapatellar cellular blue naevus over 12 years in a middle-aged woman. Staging investigations revealed a distant subcutaneous metastasis of the right thigh. Immunohistochemistry of the primary lesion and all recurrences showed S-100, HMB-45, NKI/C-3 and Ki-67 positive cells. However, non-malignant cellular blue naevi from five consecutive other patients were all Ki-67 negative. The change from negative to positive Ki-67 responsivity may therefore be a valuable marker of malignant and metastatic potential in early cellular blue naevi. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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