[The late effects of the toxic action of platinum-containing cytostatic preparations on rat progeny].

Autor: Borovskaia TG, Smirnova ME, Filippova MV, Fomina TI, Gol'dberg VE
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1996 Jul-Aug; Vol. 59 (4), pp. 40-2.
Abstrakt: Experiments on Wistar rats studied the state of the posterity born as a result of mating of intact females with males, who were injected with the antitumor drug platidiam one month before mating (once, intravenously, maximal tolerance dose). The pre- and postimplantation death rate did not grow in female rats mated with test males. However, the fetuses showed visceral anomalies and delayed development of skeleton. A decrease in the muscle tone, as well as ability for the training and extrapolation behavior, were observed in some newborn rat pups.
Databáze: MEDLINE