| Autor: |
Karpova MR, Vorob'eva MS, Kushch AA, Kiseleva NN, Rasshchepkina MN, Ladyzhenskaia IP, Mel'nikova EE, Shpilevaia MV, Amanadze SN, Vorovich MF, et. al. |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 1995 Sep-Oct; Vol. 40 (5), pp. 205-8. |
| Abstrakt: |
Comparative analysis of the characteristics of tick-borne encephalitis (TBE) strain 205 used for the production of vaccine against TBE and of its variants obtained by passages in mouse brain showed the stability of such properties as infective activity, neurovirulence, sensitivity to physical (heating to 50 C) and chemical (sodium deoxycholate treatment) factors. At the same time increased neurovirulence of variants 205/M10 and 205/M20, which undergone through 10 and 20 passages in white mouse brain, for low-sensitive Syrian hamsters was revealed. Use of a panel of 5 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein E and of 4 monoclonal antibodies to protein NS3 helped differentiate between not only strains 205 and Sofyin, but between variants of strain 205 as well. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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