| Autor: |
Van den Berg L; Department of Neurology, Columbia Presbyterian Medical Center, New York, USA., Hays AP, Nobile-Orazio E, Kinsella LJ, Manfredini E, Corbo M, Rosoklija G, Younger DS, Lovelace RE, Trojaborg W, Lange DE, Goldstein S, Delfiner JS, Sadiq SA, Sherman WH, Latov N |
| Jazyk: |
angličtina |
| Zdroj: |
Muscle & nerve [Muscle Nerve] 1996 May; Vol. 19 (5), pp. 637-43. |
| DOI: |
10.1002/(SICI)1097-4598(199605)19:5<637::AID-MUS12>3.0.CO;2-K |
| Abstrakt: |
We compared the binding of human antibodies from patients with neuropathy to the myelin-associated glycoprotein (MAG), to its cross-reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme-linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti-MAG or -SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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