| Autor: |
Ayers GJ, Goudie JH, Reed K, Burnett D |
| Jazyk: |
angličtina |
| Zdroj: |
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 1977 Apr 01; Vol. 76 (1), pp. 113-24. |
| DOI: |
10.1016/0009-8981(77)90124-3 |
| Abstrakt: |
An automated gas-liquid chromatographic technique for the routine determination of phenobarbitone, primidone and phenytoin using a nitrogen-detector is described. The high selectivity of the detector for nitrogen-containing compounds allows a direct extraction procedure and the use of a phenytoin analogue as an internal standard obviates the need for accurate aliquot measurement after extraction. The anticonvulsants are chromatographed as methyl derivatives produced by on-column methylation with trimethylphenyl ammonium hydroxide following automatic liquid injection. Quality control data from an internal quality control scheme is presented and the performance of the laboratory in an inter-laboratory control scheme is reported and discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
