Crystal-cell interaction inhibition by polysaccharides.
| Autor: | Verkoelen CF; Department of Urology, AEM-Unit, Erasmus University, Rotterdam, The Netherlands., Romijn JC, Cao LC, Boevé ER, De Bruijn WC, Schröder FH |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of urology [J Urol] 1996 Feb; Vol. 155 (2), pp. 749-52. |
| Abstrakt: | Purpose: We studied the effect of polysaccharides on interactions between calcium oxalate monohydrate (COM) crystals and cultured renal cells. Materials and Methods: Monolayers of Madin-Darby canine kidney (MDCK) cells were incubated with radiolabeled crystals in the presence of various concentrations of natural glycosaminoglycans (GAGs) and semisynthetic polysaccharides (SSPs). Results: While most GAGs were found to have relatively little effect, SSPs (SP54, G871 and G872) were potent inhibitors of crystal-cell association. Pretreatment of crystals, but not of cells, was similarly effective, suggesting polysaccharide-induced modification of crystal surface properties. Conclusions: This result further supports the idea that SSPs, and especially G872, are of potential interest for treatment of recurrent stone disease. |
| Databáze: | MEDLINE |
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