| Autor: |
Garber TL; Texas A & M University, Department of Veterinary Pathology, College Station 77843., Hughes AL, Watkins DI, Templeton JW |
| Jazyk: |
angličtina |
| Zdroj: |
Immunogenetics [Immunogenetics] 1994; Vol. 39 (4), pp. 257-65. |
| DOI: |
10.1007/BF00188788 |
| Abstrakt: |
Serological data identify a single major histocompatibility complex (MHC) class I locus in cattle. Molecular data, however, demonstrate the presence of at least two cattle MHC (BoLA) class I loci. To investigate the number of transcribed BoLA class I genes, we amplified cattle cDNA by using a single MHC class I-specific primer that hybridized to a conserved region of exon 4 and a non-specific 3' primer. Six BoLA class I cDNAs have been cloned and sequenced from a Bos taurus bull heterozygous for BoLA class I serological antigens, demonstrating the presence of a minimum of three loci. Sequence comparisons suggested that one of these cDNAs may be an unexpressed allele or the product of a nonclassical locus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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