| Autor: |
Kadota RP; Children's Hospital and Health Center, San Diego, Calif., Mandell LR, Fontanesi J, Kovnar EH, Krischer J, Kun LE, Friedman HS |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric neurosurgery [Pediatr Neurosurg] 1994; Vol. 20 (4), pp. 221-5. |
| DOI: |
10.1159/000120794 |
| Abstrakt: |
A phase I Pediatric Oncology Group Study was performed combining 7,020 cGy hyperfractionated irradiation (117 cGy twice daily separated by 6 h) with increasing concurrent doses of cisplatin given with the intent of radiosensitization as treatment for children with newly diagnosed brain stem tumors. Cisplatin was infused over 120 h on weeks 1, 3, and 5 during a 6-week radiotherapy course. The following cisplatin dose levels were studied: (1) 50 mg/m2/120 h, (2) 75 mg/m2/120 h and (3) 100 mg/m2/120 h. Sixteen of 17 children completed therapy. One child expired after 2 days of treatment secondary to massive intratumoral hemorrhage. At cisplatin dose level 3 (100 mg/m2/120 h), grade 2-4 myelosuppression was encountered in 3 of 5 evaluable patients. Otherwise, no other excessive toxicities, including renal and ototoxicity, were noted. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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