| Autor: |
Kent SJ; Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, University of Western Ontario, London, Canada., Karlik SJ, Cannon C, Hines DK, Yednock TA, Fritz LC, Horner HC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroimmunology [J Neuroimmunol] 1995 Apr; Vol. 58 (1), pp. 1-10. |
| DOI: |
10.1016/0165-5728(94)00165-k |
| Abstrakt: |
In experimental allergic encephalomyelitis (EAE), circulating leukocytes enter the central nervous system (CNS) producing inflammation, myelin damage and paralysis. Prevention of leukocyte infiltration by an antibody against alpha 4 integrin suppressed clinical and pathological features of EAE in the guinea pig. Rapid clearance of leukocytes from the CNS and reversal of clinical findings were observed when anti-alpha 4 treatment was administered during active disease. Clinical improvement was accompanied by a marked decrease in abnormal pathological findings, including demyelination. Therefore anti-alpha 4 is an effective treatment of EAE and may be similarly useful in the treatment of autoimmune diseases such as multiple sclerosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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