| Autor: |
Udayakumar AM; Department of Pathology, Kidwai Memorial Institute of Oncology, Karnataka, India., Bhargava MK |
| Jazyk: |
angličtina |
| Zdroj: |
Annales de genetique [Ann Genet] 1994; Vol. 37 (4), pp. 192-5. |
| Abstrakt: |
In a study comprised of 53 breast cancer patients, chosen for determining the cytogenetic damage to peripheral blood lymphocytes (PBL) due to cancer therapy, eleven patients revealed chromosomal abnormalities in 3.18% of cells prior to any such therapy. Age matched controls showed 0.18% abnormal cells. Statistical analysis of the abnormal cells in patients prior to therapy and normal controls revealed significant values at 1% level (p < 0.01). The factors causing "chromosome instability" causing chromosome breakage or whether any clastogenic metabolites produced by the tumor itself is triggering neoplastic transformation are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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