| Autor: |
Warters RL; Department of Radiology, University of Utah Health Sciences Center, Salt Lake City 84132., Lyons BW, Chen DJ, Sato K |
| Jazyk: |
angličtina |
| Zdroj: |
Mutation research [Mutat Res] 1993 Jan; Vol. 293 (2), pp. 91-8. |
| DOI: |
10.1016/0921-8777(93)90061-k |
| Abstrakt: |
The induction and repair of radiation-induced DNA damage was assessed in 3 mouse cell lines, including the parental L cell line, a radiation-sensitive, SL3-147 mutant cell line and the H5 revertant to radiation resistance. The yield of neither radiation-induced DNA single- nor double-strand breaks could explain the variable sensitivity of the 3 cell lines. Closure of DNA single-strand breaks proceeded at a similar rate in both the L and SL3-147 cell lines. Closure of DNA double-strand breaks however was significantly slower and less complete in the SL3-147 cell line than in either of the radiation-resistant cell lines. The results are consistent with the increased radiation sensitivity of the SL3-147 cell line resulting from a defect in their ability to repair radiation-induced DNA double-strand breaks. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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