| Autor: |
Breuer JH, Harsányi V, Solti V, Hollán SR |
| Jazyk: |
angličtina |
| Zdroj: |
Haemostasis [Haemostasis] 1981; Vol. 10 (3), pp. 134-40. |
| DOI: |
10.1159/000214397 |
| Abstrakt: |
Platelet phospholipids were analyzed in patients with thrombocytosis due to myeloproliferative disorders and secondary thrombocytosis. A significant increase of phosphatidylcholine together with a decrease of sphingomyelin was observed in each of the 8 patients with primary thrombocythaemia and in each of the 5 patients with excessive thrombocytosis due to primary polycythaemia. The phospholipid pattern of the 3 patients with secondary thrombocytosis did not differ from that of the normal controls. This marked difference in the platelet phospholipids may be helpful in distinguishing secondary thrombocytosis persisting for a prolonged period of time after splenectomy from previously unrecognized primary thrombocythaemia unmasked by splenectomy. The decreased sphingomyelin/lecithin ratio of platelets in primary thrombocythaemia may interfere with platelet function by increasing the fluidity of their membrane. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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